CHMP5 controls bone turnover rates by dampening NF-κB activity in osteoclasts
Rockefeller University Press -- Journal of Experimental Medicine
DOI 10.1084/jem.20150407

Greenblatt et al. show that deletion of CHMP5 in osteoclasts leads to increased bone resorption coupled with exuberant osteoblast activity, resembling an early onset form of human Paget’s Disease of Bone