Direct arylation catalysis with chloro[8-(dimesitylboryl)quinoline-κN]copper(I)
Beilstein Institut -- Beilstein Journal of Organic Chemistry
DOI 10.3762/bjoc.12.272
Keyword(s)
  1. catalysis
  2. C–C coupling
  3. C–H activation
  4. copper
  5. direct arylation
Abstract(s)

We report direct arylation of arylhalides with unactivated sp2 C–H bonds in benzene and naphthalene using a copper(I) catalyst featuring an ambiphilic ligand, (quinolin-8-yl)dimesitylborane. Direct arylation could be achieved with 0.2 mol % catalyst and 3 equivalents of base (KO(t-Bu)) at 80 °C to afford TON ≈160–190 over 40 hours.