INDUCTION AND PROMOTION OF γ-GLUTAMYLTRANSPEPTIDASE-POSITIVE FOCI IN THE RAT LIVER BY METHYLGLYOXAL
Wiley -- Japanese Journal of Cancer Research
DOI 10.1111/j.1349-7006.1988.tb02218.x
Keyword(s)
  1. Methylglyoxal
  2. γ‐Glutamyltranspeptidase‐positive foci
  3. Rat liver
Abstract(s)

The effect of pre‐(initiation) and post‐(promotion) administration of methylglyoxal (MG) on the induction of γ‐glutamyltranspeptidase (GGT)‐positive foci in the liver of F344 male rats was investigated. GGT‐positive foci were produced in doserelated amounts by 0.05 and 0.2% MG in drinking water, either when administered to uninitiated rats or when given in the promotion phase.