Methylated Vnn1 at promoter regions induces asthma occurrence via the PI3K/Akt/NFκB-mediated inflammation in IUGR mice
The Company of Biologists Ltd -- Biology Open
DOI 10.1242/bio.049106
Keyword(s)
  1. Vascular non-inflammatory molecule 1 (vannin-1)
  2. Methylation
  3. Protein kinase B (Akt)
  4. NFκB
  5. Asthma
  6. Intrauterine growth retardation (IUGR)
Abstract(s)
Abstract

Summary: Vascular non-inflammatory molecule 1 (vannin-1) is elevated in intrauterine growth retardation (IUGR) asthmatic mice, leading to activation of the PI3K/Akt/NFκB pathway responsible for bronchial oxidative stress and hyperresponsiveness.