JAMA Netw Open
American Medical Association (AMA)
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Associations of Widowhood and β-Amyloid With Cognitive Decline in Cognitively Unimpaired Older Adults
Volume: 3, Issue: 2
DOI 10.1001/jamanetworkopen.2020.0121

Highlights

Notes

Abstract

Key Points

Question

Is widowhood a specific risk factor associated with more rapid cognitive decline among cognitively unimpaired older adults with higher levels of brain β-amyloid, the Alzheimer disease biomarker?

Findings

In this cohort study of 257 community-dwelling cognitively unimpaired older adults, widowhood and β-amyloid were additively and interactively associated with cognitive decline. These results were independent of demographic factors, cardiovascular disease risk, depression, health-related behaviors, and social support factors.

Meaning

These findings suggest that widowhood may be an understudied risk factor for cognitive decline associated with Alzheimer disease and highlight the need for increased research and clinical attention to this high-risk group.

https://www.researchpad.co/tools/openurl?pubtype=article&doi=10.1001/jamanetworkopen.2020.0121&title=Associations of Widowhood and β-Amyloid With Cognitive Decline in Cognitively Unimpaired Older Adults&author=&keyword=&subject=Research,Original Investigation,Online Only,Geriatrics,