J Vet Intern Med
Wiley
image
Effects of arginine and ornithine supplementation to a high‐protein diet on selected cellular immune variables in adult cats
Volume: 34, Issue: 2
DOI 10.1111/jvim.15736

Highlights

Notes

Abstract

Abstract

Background

Dietary protein and amino acid intake and composition can modulate immune function.

Objectives

To evaluate the effects of high‐protein intake and arginine and ornithine supplementation on feline immune cells.

Animals

Ten healthy cats.

Methods

Experimental study. Cats received a high‐protein basal diet as a single daily meal. A crossover design was applied with treatments being basal diet (w/o); basal diet with arginine supplementation (+50, 75, 100% compared to the arginine provision by the basal diet; Arg 1‐3); and basal diet with ornithine supplementation (+100, 150, 200% compared to the arginine provision by the basal diet; Orn 1‐3). Blood samples were collected at the end of each 11‐day treatment period.

Results

Mitogen‐stimulated proliferative activity of blood leukocytes revealed a quadratic effect for the dietary supplementation of arginine (P = .02) and ornithine (P = .03) (means for ConA‐stimulation: w/o = 6.96; Arg 1 = 9.31; Arg 2 = 11.4; Arg 3 = 8.04; Orn 1 = 15.4; Orn 2 = 9.43; Orn 3 = 9.28; pooled SEM: 0.96). The number (% gated) of phagocytic granulocytes linearly decreased with increasing dietary concentrations of arginine (P = .05) and ornithine (P = .03) (means: w/o = 95.5; Arg 1 = 93.0; Arg 2 = 92.5; Arg 3 = 92.6; Orn 1 = 92.6; Orn 2 = 92.6; Orn 3 = 91.5; pooled SEM = 0.44).

Conclusions and Clinical Importance

This study could demonstrate immunomodulating properties of dietary arginine and ornithine in cats.

Keywords
https://www.researchpad.co/tools/openurl?pubtype=article&doi=10.1111/jvim.15736&title=Effects of arginine and ornithine supplementation to a high‐protein diet on selected cellular immune variables in adult cats&author=&keyword=feline,immune system,phagocytic granulocytes,proliferation,&subject=Standard Article,SMALL ANIMAL,Standard Articles,Nutrition/Metabolism,