Is There an Association Between COVID-19 Mortality and the Renin-Angiotensin System? A Call for Epidemiologic Investigations
Oxford University Press -- Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
DOI 10.1093/cid/ciaa329
  1. COVID-19
  2. SARS-CoV-2
  3. angiotensin-converting enzyme 2
  4. renin-angiotensin system
  5. cardiovascular disease

The association between coronavirus disease 2019 (COVID-19) mortality and cardiovascular disease is likely mediated by dysregulation of the renin-angiotensin system (RAS). Pharmacoepidemiologic studies are needed to clarify whether RAS inhibition mediates this association and is helpful or harmful.