DnaJ-PKAc fusion induces liver inflammation in a zebrafish model of fibrolamellar carcinoma
The Company of Biologists Ltd -- Disease Models & Mechanisms
DOI 10.1242/dmm.042564
Keyword(s)
  1. Fibrolamellar carcinoma
  2. Liver
  3. Inflammation
  4. Early progression
  5. Non-invasive imaging
Abstract(s)
Abstract

Summary: Inflammation and Caspase-a activation occur early in a new zebrafish model for fibrolamellar carcinoma (FLC). Pharmacological inhibition of TNF╬▒ secretion and caspase-1 might be useful approaches to treat FLC patients.