Curcumin’s Effect оn COX-2 аnd IL-10 Serum in Preeclampsia’s Patient Undergo Sectio Caesarea with Spinal Anesthesia
ID Design 2012/DOOEL Skopje -- Open Access Macedonian Journal of Medical Sciences
DOI 10.3889/oamjms.2019.426
  1. Curcumin
  2. Cyclooxygenase 2 (COX-2)
  3. Interleukin-10 (IL-10)
  4. Preeclampsia
  5. Spinal Anesthesia


Curcumin is a major component in curcuminoid which acts as an anti-inflammatory agent. Curcumin affects several biological markers that are thought to play a role in the pathogenesis of preeclampsia such as IL-10 and COX-2, resulting in an improvement in pregnant women with preeclampsia.


To see the effect of perioperative curcumin administration on IL-10 and COX-2 in preeclamptic patients undergoing caesarean section under spinal anaesthesia.


This study was a double-blind, randomised clinical trial conducted at Pirngadi Hospital, USU Hospital and Sundari General Hospital Medan as a hospital network of Faculty of Medicine, North Sumatra University. Group 1 received a drug containing curcumin (as a treatment), and another group received a placebo (as a control).


There were no significant differences in the median values of COX-2 and IL-10 before and after treatment and also the p-values were greater than 0.05 in both groups (control and treatment).


There is no significant difference between the use of curcumin on serum COX-2 and IL-10 levels.