Nisin J, a Novel Natural Nisin Variant, Is Produced by Staphylococcus capitis Sourced from the Human Skin Microbiota
American Society for Microbiology -- Journal of Bacteriology
DOI 10.1128/JB.00639-19
Keyword(s)
  1. antimicrobial agents
  2. antimicrobial peptides
  3. antimicrobial structure
  4. bacteriocins
  5. microbiota
  6. natural antimicrobial products
  7. skin microbiota
  8. nisin
Abstract(s)

This study describes the characterization of nisin J, the first example of a natural nisin variant, produced by a human skin isolate of staphylococcal origin. Nisin J displays inhibitory activity against a wide range of bacterial targets, including MRSA. This work demonstrates the potential of human commensals as a source for novel antimicrobials that could form part of the solution to antibiotic resistance across a broad range of bacterial pathogens.