The pathophysiology of nonalcoholic fatty liver disease (NAFLD) is still not completely understood, nor are there any approved therapies for treating this disorder, so there is a need for further research. Rodent models are typically used as surrogates for human disease and this article provides examples of how targeted nutrient manipulations in rodent diets influence NAFLD development in mice, rats, and hamsters. This article also focuses on study design details including nutritional components of the diets (and their controls), proper control diet choice, animal model/strain, and length of the study to clearly outline the strengths and drawbacks of the different dietary methods of inducing NAFLD in rodents.
https://www.researchpad.co/tools/openurl?pubtype=article&doi=10.1093/cdn/nzaa078&title=Targeted Nutrient Modifications in Purified Diets Differentially Affect Nonalcoholic Fatty Liver Disease and Metabolic Disease Development in Rodent Models&author=Sridhar Radhakrishnan,Jia-Yu Ke,Michael A Pellizzon,&keyword=purified diet,high-fat diet,methionine- and choline-deficient diet,fructose,cholesterol,nonalcoholic fatty liver disease,metabolic disease,mice,rats,hamsters,&subject=RESEARCH METHODOLOGY/STUDY DESIGN,Research Methodology and Study Design,AcademicSubjects/MED00060,
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