The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
Oxford University Press
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Uncontrolled Diabetes as an Associated Factor with Dynapenia in Adults Aged 50 Years or Older: Sex Differences
Volume: 75, Issue: 6
DOI 10.1093/gerona/glz257
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Abstract

BackgroundEpidemiological studies demonstrate an association between diabetes and low neuromuscular strength (NMS). However, none have grouped participants into nondiabetics (ND), undiagnosed diabetics (UDD), controlled diabetics (CD), and uncontrolled diabetics (UCD) or investigated what glycated hemoglobin levels (HbA1c) are associated with low NMS (dynapenia) by sex.MethodsWe analyzed the association between UDD, CD, and UCD and dynapenia, the extent to which the different groupings of these individuals modifies this association and the association between HbA1c levels and NMS, by sex, in a cross-sectional study involving 5,290 participants ≥50 years from the ELSA study. In the first two analyses, logistic regression models were used with dynapenia (grip strength <26 kg in men and <16 kg in women) as outcome and diabetes (ND, UDD, CD, and UCD) as exposure. Next, linear regression was performed with grip strength as the outcome, and the participants were classified based on HbA1c level as exposure. The models were adjusted by sociodemographic, behavioral, and clinical characteristics.ResultsCompared to ND, only UCD was associated with dynapenia (men OR = 2.37 95% CI 1.36–4.14; women OR = 1.67 95% CI 1.01–2.79). This association was less clear, particularly in women, when CD and UCD groups were merged. HbA1c ≥6.5% in men and ≥8.0% in women were associated with lower NMS.ConclusionsUCD increases the chance of dynapenia in both sexes. The different groupings based on diabetes status modify the association between UCD and dynapenia. The threshold of HbA1c associated with reduced NMS is lower in men compared to women.

Keywords
https://www.researchpad.co/tools/openurl?pubtype=article&doi=10.1093/gerona/glz257&title=Uncontrolled Diabetes as an Associated Factor with Dynapenia in Adults Aged 50 Years or Older: Sex Differences&author=Clarice Cavalero Nebuloni,Roberta de Oliveira Máximo,Cesar de Oliveira,Tiago da Silva Alexandre,Anne Newman,&keyword=Glycated hemoglobin,Hyperglycemia,Neuromuscular strength,Dynapenia,Aging,&subject=THE JOURNAL OF GERONTOLOGY: Medical Sciences,Muscles, Gait, and Falls,AcademicSubjects/MED00280,AcademicSubjects/SCI00960,