PLoS Neglected Tropical Diseases
Public Library of Science
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Potency and breadth of human primary ZIKV immune sera shows that Zika viruses cluster antigenically as a single serotype
Volume: 14, Issue: 4
DOI 10.1371/journal.pntd.0008006
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Abstract

The recent emergence of Zika virus as an important human pathogen has raised questions about the durability and breadth of Zika virus immunity following natural infection in humans. While global epidemic patterns suggest that Zika infection elicits a protective immune response that is likely to offer long-term protection against repeat infection by other Zika viruses, only one study to date has formally examined the ability of human Zika immune sera to neutralize different Zika viruses. That study was limited because it evaluated human immune sera no more than 13 weeks after Zika virus infection and tested a relatively small number of Zika viruses. In this study, we examine twelve human Zika immune sera as far as 3 years after infection and test the sera against a total of eleven Zika virus isolates. Our results confirm the earlier study and epidemic patterns that suggest Zika virus exists in nature as a single serotype, and infection with one Zika virus can be expected to elicit protective immunity against repeat infection by any Zika virus for years to decades after the first infection.

https://www.researchpad.co/tools/openurl?pubtype=article&doi=10.1371/journal.pntd.0008006&title=Potency and breadth of human primary ZIKV immune sera shows that Zika viruses cluster antigenically as a single serotype&author=Chad D. Nix,Jonathan Salberg,Felicity J. Coulter,Bettie W. Kareko,Zoe L. Lyski,Brian L. Booty,William B. Messer,Sujatha Sunil,&keyword=&subject=Research Article,Biology and life sciences,Organisms,Viruses,RNA viruses,Flaviviruses,Zika Virus,Biology and Life Sciences,Microbiology,Medical Microbiology,Microbial Pathogens,Viral Pathogens,Flaviviruses,Zika Virus,Medicine and Health Sciences,Pathology and Laboratory Medicine,Pathogens,Microbial Pathogens,Viral Pathogens,Flaviviruses,Zika Virus,Biology and Life Sciences,Organisms,Viruses,Viral Pathogens,Flaviviruses,Zika Virus,Biology and Life Sciences,Anatomy,Body Fluids,Blood,Blood Serum,Immune Serum,Medicine and Health Sciences,Anatomy,Body Fluids,Blood,Blood Serum,Immune Serum,Biology and Life Sciences,Physiology,Body Fluids,Blood,Blood Serum,Immune Serum,Medicine and Health Sciences,Physiology,Body Fluids,Blood,Blood Serum,Immune Serum,Biology and life sciences,Organisms,Viruses,RNA viruses,Flaviviruses,Dengue Virus,Biology and Life Sciences,Microbiology,Medical Microbiology,Microbial Pathogens,Viral Pathogens,Flaviviruses,Dengue Virus,Medicine and Health Sciences,Pathology and Laboratory Medicine,Pathogens,Microbial Pathogens,Viral Pathogens,Flaviviruses,Dengue Virus,Biology and Life Sciences,Organisms,Viruses,Viral Pathogens,Flaviviruses,Dengue Virus,Research and Analysis Methods,Immunologic Techniques,Antigenic Cartography,Biology and Life Sciences,Genetics,Microbial Genetics,Biology and Life Sciences,Genetics,Human Genetics,Biology and Life Sciences,Physiology,Immune Physiology,Antibodies,Medicine and Health Sciences,Physiology,Immune Physiology,Antibodies,Biology and Life Sciences,Immunology,Immune System Proteins,Antibodies,Medicine and Health Sciences,Immunology,Immune System Proteins,Antibodies,Biology and Life Sciences,Biochemistry,Proteins,Immune System Proteins,Antibodies,Biology and Life Sciences,Physiology,Immune Physiology,Antigens,Antigenic Variation,Medicine and Health Sciences,Physiology,Immune Physiology,Antigens,Antigenic Variation,Biology and Life Sciences,Immunology,Immune System Proteins,Antigens,Antigenic Variation,Medicine and Health Sciences,Immunology,Immune System Proteins,Antigens,Antigenic Variation,Biology and Life Sciences,Biochemistry,Proteins,Immune System Proteins,Antigens,Antigenic Variation,