PLoS Pathogens
Public Library of Science
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Murine gammaherpesvirus infection is skewed toward Igλ+ B cells expressing a specific heavy chain V-segment
Volume: 16, Issue: 4
DOI 10.1371/journal.ppat.1008438
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Abstract

Murine gammaherpesvirus 68 is a rodent pathogen that is closely related to the human gammaherpesviruses Epstein-Barr virus and Kaposi’s sarcoma-associated virus. All know gammaherpesviruses are associated with the development of lymphomas, as well as other cancers, in a small subset of infected individuals–particularly those with underlying defects in their immune system (i.e., transplant recipients and HIV infected patients). Because there are very limited small animal models for the human gammaherpesviruses, studies on murine gammaherepsviruses 68 can provide important insights into critical aspects of gammaherpesvirus infections and the association of these viruses with disease development. Another feature of all gammaherpesviruses is their ability to establish a chronic infection of their host–where the virus is maintained for the lifetime of the infected individual. The major target cell harboring chronic gammaherepsvirus infection are B lymphocytes–the cells in the immune system that produce antibodies in response to infections. Here we provide a detailed characterization of the populations of B lymphocytes that become infected by murine gammaherpesvirus 68. This has led to the identification of a specific population of B lymphocytes that is preferentially infected by the virus. This supports a model in which murine gammaherpesvirus infection of B lymphocytes is not random. However, it remains unclear why the virus targets this specific population of B cells for infection.

https://www.researchpad.co/tools/openurl?pubtype=article&doi=10.1371/journal.ppat.1008438&title=Murine gammaherpesvirus infection is skewed toward Igλ+ B cells expressing a specific heavy chain V-segment&author=Christopher M. Collins,Christopher D. Scharer,Thomas J. Murphy,Jeremy M. Boss,Samuel H. Speck,Dirk P. Dittmer,&keyword=&subject=Research Article,Biology and Life Sciences,Cell Biology,Cellular Types,Animal Cells,Immune Cells,Antibody-Producing Cells,B Cells,Biology and Life Sciences,Immunology,Immune Cells,Antibody-Producing Cells,B Cells,Medicine and Health Sciences,Immunology,Immune Cells,Antibody-Producing Cells,B Cells,Biology and Life Sciences,Cell Biology,Cellular Types,Animal Cells,Blood Cells,White Blood Cells,B Cells,Biology and Life Sciences,Cell Biology,Cellular Types,Animal Cells,Immune Cells,White Blood Cells,B Cells,Biology and Life Sciences,Immunology,Immune Cells,White Blood Cells,B Cells,Medicine and Health Sciences,Immunology,Immune Cells,White Blood Cells,B Cells,Biology and Life Sciences,Cell Biology,Cellular Types,Animal Cells,Blood Cells,White Blood Cells,Plasma Cells,Biology and Life Sciences,Cell Biology,Cellular Types,Animal Cells,Immune Cells,White Blood Cells,Plasma Cells,Biology and Life Sciences,Immunology,Immune Cells,White Blood Cells,Plasma Cells,Medicine and Health Sciences,Immunology,Immune Cells,White Blood Cells,Plasma Cells,Biology and Life Sciences,Physiology,Immune Physiology,Antibodies,Medicine and Health Sciences,Physiology,Immune Physiology,Antibodies,Biology and Life Sciences,Immunology,Immune System Proteins,Antibodies,Medicine and Health Sciences,Immunology,Immune System Proteins,Antibodies,Biology and Life Sciences,Biochemistry,Proteins,Immune System Proteins,Antibodies,Biology and Life Sciences,Molecular Biology,Molecular Biology Techniques,Artificial Gene Amplification and Extension,Polymerase Chain Reaction,Research and Analysis Methods,Molecular Biology Techniques,Artificial Gene Amplification and Extension,Polymerase Chain Reaction,Research and Analysis Methods,Immunologic Techniques,Immunoassays,Enzyme-Linked Immunoassays,Biology and life sciences,Organisms,Viruses,DNA viruses,Herpesviruses,Biology and Life Sciences,Microbiology,Medical Microbiology,Microbial Pathogens,Viral Pathogens,Herpesviruses,Medicine and Health Sciences,Pathology and Laboratory Medicine,Pathogens,Microbial Pathogens,Viral Pathogens,Herpesviruses,Biology and Life Sciences,Organisms,Viruses,Viral Pathogens,Herpesviruses,Biology and life sciences,Cell biology,Cellular types,Animal cells,Immune cells,Antibody-producing cells,B cells,Memory B cells,Biology and life sciences,Immunology,Immune cells,Antibody-producing cells,B cells,Memory B cells,Medicine and health sciences,Immunology,Immune cells,Antibody-producing cells,B cells,Memory B cells,Biology and life sciences,Cell biology,Cellular types,Animal cells,Blood cells,White blood cells,B cells,Memory B cells,Biology and life sciences,Cell biology,Cellular types,Animal cells,Immune cells,White blood cells,B cells,Memory B cells,Biology and life sciences,Immunology,Immune cells,White blood cells,B cells,Memory B cells,Medicine and health sciences,Immunology,Immune cells,White blood cells,B cells,Memory B cells,Biology and Life Sciences,Molecular Biology,Molecular Biology Techniques,Cloning,Molecular Cloning,Research and Analysis Methods,Molecular Biology Techniques,Cloning,Molecular Cloning,