PLoS Pathogens
Public Library of Science
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Differential expression of interferon-lambda receptor 1 splice variants determines the magnitude of the antiviral response induced by interferon-lambda 3 in human immune cells
Volume: 16, Issue: 4
DOI 10.1371/journal.ppat.1008515
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Abstract

Type III IFNs (IFN-λs) are antiviral cytokines that are thought to act on specific subsets of cells, especially to protect mucosal barriers. Here, we demonstrate that IFN-λ3 differentially binds multiple human immune cell subsets, indicating the specific receptor subunit, IFN-λR1, is more broadly expressed in the human immune system, compared to published mouse models. IFN-λR1 expression increased after cellular activation, and antiviral responses were inhibited by a soluble version of the receptor. The direct interaction of IFN-λs with human immune cells, and specific regulation of IFN-λR1 expression, has broad mechanistic implications in the modulation of inflammatory or anti-cancer immune responses, and future antiviral therapies.

https://www.researchpad.co/tools/openurl?pubtype=article&doi=10.1371/journal.ppat.1008515&title=Differential expression of interferon-lambda receptor 1 splice variants determines the magnitude of the antiviral response induced by interferon-lambda 3 in human immune cells&author=Deanna M. Santer,Gillian E. S. Minty,Dominic P. Golec,Julia Lu,Julia May,Afshin Namdar,Juhi Shah,Shokrollah Elahi,David Proud,Michael Joyce,D. Lorne Tyrrell,Michael Houghton,Jacob S. Yount,&keyword=&subject=Research Article,Biology and Life Sciences,Cell Biology,Cellular Types,Animal Cells,Blood Cells,White Blood Cells,T Cells,Biology and Life Sciences,Cell Biology,Cellular Types,Animal Cells,Immune Cells,White Blood Cells,T Cells,Biology and Life Sciences,Immunology,Immune Cells,White Blood Cells,T Cells,Medicine and Health Sciences,Immunology,Immune Cells,White Blood Cells,T Cells,Biology and Life Sciences,Cell Biology,Cellular Types,Animal Cells,Immune Cells,Biology and Life Sciences,Immunology,Immune Cells,Medicine and Health Sciences,Immunology,Immune Cells,Biology and Life Sciences,Cell Biology,Cellular Types,Animal Cells,Immune Cells,Antibody-Producing Cells,B Cells,Biology and Life Sciences,Immunology,Immune Cells,Antibody-Producing Cells,B Cells,Medicine and Health Sciences,Immunology,Immune Cells,Antibody-Producing Cells,B Cells,Biology and Life Sciences,Cell Biology,Cellular Types,Animal Cells,Blood Cells,White Blood Cells,B Cells,Biology and Life Sciences,Cell Biology,Cellular Types,Animal Cells,Immune Cells,White Blood Cells,B Cells,Biology and Life Sciences,Immunology,Immune Cells,White Blood Cells,B Cells,Medicine and Health Sciences,Immunology,Immune Cells,White Blood Cells,B Cells,Biology and Life Sciences,Cell Biology,Cell Physiology,Cell Binding,Biology and Life Sciences,Cell Biology,Cellular Types,Animal Cells,Blood Cells,White Blood Cells,Neutrophils,Biology and Life Sciences,Cell Biology,Cellular Types,Animal Cells,Immune Cells,White Blood Cells,Neutrophils,Biology and Life Sciences,Immunology,Immune Cells,White Blood Cells,Neutrophils,Medicine and Health Sciences,Immunology,Immune Cells,White Blood Cells,Neutrophils,Biology and Life Sciences,Cell Biology,Cellular Types,Animal Cells,Epithelial Cells,Biology and Life Sciences,Anatomy,Biological Tissue,Epithelium,Epithelial Cells,Medicine and Health Sciences,Anatomy,Biological Tissue,Epithelium,Epithelial Cells,Biology and Life Sciences,Cell Biology,Cellular Types,Animal Cells,Blood Cells,White Blood Cells,Monocytes,Biology and Life Sciences,Cell Biology,Cellular Types,Animal Cells,Immune Cells,White Blood Cells,Monocytes,Biology and Life Sciences,Immunology,Immune Cells,White Blood Cells,Monocytes,Medicine and Health Sciences,Immunology,Immune Cells,White Blood Cells,Monocytes,Research and Analysis Methods,Chemical Characterization,Binding Analysis,Cell Binding Assay,