PLoS Pathogens
Public Library of Science
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ICOS signaling promotes a secondary humoral response after re-challenge with Plasmodium chabaudi chabaudi AS
Volume: 16, Issue: 4
DOI 10.1371/journal.ppat.1008527
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Abstract

Malaria, which is caused by the protozoan parasite Plasmodium, remains a major global health problem, as over 400,000 people die from this disease every year. Further understanding of the mechanisms that contribute to protective immunity against this parasite will serve to promote the development of an effective vaccine. Here, we describe the importance of the co-stimulatory molecule ICOS during secondary infection with the rodent parasite Plasmodium chabaudi chabaudi AS. We show that ICOS promotes the expansion of memory T cells, their acquisition of a secondary follicular helper T (Tfh) cell phenotype, and their ability to provide help to MBCs after reinfection. While ICOS deficient mice control the initial parasite load after re-challenge, the absence of ICOS leads to higher relapsing parasitemia compared to wild-type mice. We establish that the lack of expansion of effector cells with a Tfh cell phenotype in Icos-/- mice prevents germinal center formation after secondary infection. Thus, we show that ICOS signaling in T cells promotes an effective memory T cell response and suggests that the enhancement of this co-stimulatory pathway during vaccination may enhance protective immunity to blood-stage Plasmodium infection.

https://www.researchpad.co/tools/openurl?pubtype=article&doi=10.1371/journal.ppat.1008527&title=ICOS signaling promotes a secondary humoral response after re-challenge with <i>Plasmodium chabaudi chabaudi</i> AS&author=Leah E. Latham,Daniel J. Wikenheiser,Jason S. Stumhofer,Kevin N. Couper,&keyword=&subject=Research Article,Biology and Life Sciences,Cell Biology,Cellular Types,Animal Cells,Blood Cells,White Blood Cells,T Cells,Biology and Life Sciences,Cell Biology,Cellular Types,Animal Cells,Immune Cells,White Blood Cells,T Cells,Biology and Life Sciences,Immunology,Immune Cells,White Blood Cells,T Cells,Medicine and Health Sciences,Immunology,Immune Cells,White Blood Cells,T Cells,Biology and life sciences,Cell biology,Cellular types,Animal cells,Blood cells,White blood cells,T cells,Memory T cells,Biology and life sciences,Cell biology,Cellular types,Animal cells,Immune cells,White blood cells,T cells,Memory T cells,Biology and life sciences,Immunology,Immune cells,White blood cells,T cells,Memory T cells,Medicine and health sciences,Immunology,Immune cells,White blood cells,T cells,Memory T cells,Biology and Life Sciences,Physiology,Immune Physiology,Spleen,Medicine and Health Sciences,Physiology,Immune Physiology,Spleen,Biology and Life Sciences,Cell Biology,Cellular Types,Animal Cells,Immune Cells,Antibody-Producing Cells,B Cells,Biology and Life Sciences,Immunology,Immune Cells,Antibody-Producing Cells,B Cells,Medicine and Health Sciences,Immunology,Immune Cells,Antibody-Producing Cells,B Cells,Biology and Life Sciences,Cell Biology,Cellular Types,Animal Cells,Blood Cells,White Blood Cells,B Cells,Biology and Life Sciences,Cell Biology,Cellular Types,Animal Cells,Immune Cells,White Blood Cells,B Cells,Biology and Life Sciences,Immunology,Immune Cells,White Blood Cells,B Cells,Medicine and Health Sciences,Immunology,Immune Cells,White Blood Cells,B Cells,Medicine and Health Sciences,Parasitic Diseases,Biology and Life Sciences,Parasitology,Quantitative Parasitology,Parasitemia,Biology and Life Sciences,Immunology,Immune Response,Medicine and Health Sciences,Immunology,Immune Response,Biology and Life Sciences,Genetics,Phenotypes,