Turkish Journal of Hematology
Galenos Publishing
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Garland of Erythroblasts around a Macrophage: Erythroblastic Island
Volume: 37, Issue: 2
DOI 10.4274/tjh.galenos.2019.2019.0398
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Table of Contents

Highlights

Notes

Kumar, Jain, and Chopra: Garland of Erythroblasts around a Macrophage: Erythroblastic Island

Erythroblastic islands (EBIs) were first described by Marcel Bessis in 1958 [1] as functional units of erythropoiesis where a central macrophage functions as a “nurse” cell [2].

We found a picturesque erythroblastic island with a central macrophage encircled by a garland of erythroid cells (Figure 1) in the bone marrow aspirate (BMA) of a 43-year-old man diagnosed with diffuse large B-cell lymphoma (DLBCL) on lymph node biopsy. BMA was done as a part of the staging workup, which was cellular and showed normoblastic erythroid hyperplasia and no evidence of lymphoma infiltration. Many macrophages surrounded by erythroid precursors (EBIs) were also seen.

Early descriptions of EBIs did not receive much attention because of their infrequent occurrence in BMA due to their distortion during smear preparation [2]. Some recent studies [3,4] have suggested that EBIs can boost the number of red blood cells produced in vivo during stress and can also act as potential targets in the treatment of inappropriately accelerated erythropoiesis in disease conditions like β-thalassemia and polycythemia vera. While progress is being made in understanding the role of the central macrophage of an EBI in regulating erythropoiesis, many questions remain unanswered, such as its precise physiology, clinical relevance, and contribution to the pathology of erythropoiesis in benign and malignant hematopoietic disorders.

Notes

Informed Consent:: Bone marrow examination was done as part of routine work-up of the patient after obtaining his consent. We did not collect extra samples from the patient.
Authorship Contributions:

CK and AC saw the morphology slides. CK and GJ wrote the manuscript.

Conflict of Interest:: None declared.

References

1 

    Bessis M. Erythroblastic island, functional unity of bone marrow. Rev Hematol 1958. 13: , pp.8-11

2 

    Chasis JA, Mohandas N. Erythroblastic islands: niches for erythropoiesis. Blood 2008. 112: , pp.470-478

3 

    Chow A, Huggins M, Ahmed J, Hashimoto D, Lucas D, Kunisaki Y, Pinho S, Leboeuf M, Noizat C, van Rooijen N, Tanaka M, Zhao ZJ, Bergman A, Merad M, Frenette PS. CD169+ macrophages provide a niche promoting erythropoiesis under homeostasis and stress. Nat Med 2013. 19: , pp.429-436

4 

    Ramos P, Casu C, Gardenghi S, Breda L, Crielaard BJ, Guy E, Marongiu MF, Gupta R, Levine RL, Abdel-Wahab O, Ebert BL, Van Rooijen N, Ghaffari S, Grady RW, Giardina PJ, Rivella S. Macrophages support pathological erythropoiesis in polycythemia vera and β-thalassemia. Nat Med 2013. 19: , pp.437-445

Floating objects

Bone marrow aspirate showing erythroid precursors surrounding a central macrophage: erythroblastic island (Jenner and Giemsa, 1000x).
Figure 1
Bone marrow aspirate showing erythroid precursors surrounding a central macrophage: erythroblastic island (Jenner and Giemsa, 1000x).
https://www.researchpad.co/tools/openurl?pubtype=article&doi=10.4274/tjh.galenos.2019.2019.0398&title=Garland of Erythroblasts around a Macrophage: Erythroblastic Island&author=Chandan Kumar,Garima Jain,Anita Chopra,&keyword=Erythroblastic island,Macrophage,&subject=Images in Hematology,