ResearchPad - 10071 https://www.researchpad.co Default RSS Feed en-us © 2020 Newgen KnowledgeWorks <![CDATA[Inherited Thoracic Aortic Disease]]> https://www.researchpad.co/article/elastic_article_8313 Inherited thoracic aortopathies denote a group of congenital conditions that predispose to disease of the thoracic aorta. Aortic wall weakness and abnormal aortic hemodynamic profiles predispose these patients to dilatation of the thoracic aorta, which is generally silent but can precipitate aortic dissection or rupture with devastating and often fatal consequences. Current strategies to assess the future risk of aortic dissection or rupture are based primarily on monitoring aortic diameter. However, diameter alone is a poor predictor of risk, with many patients experiencing dissection or rupture below current intervention thresholds. Developing tools that improve the risk assessment of those with aortopathy is internationally regarded as a research priority. A robust understanding of the molecular pathways that lead to aortic wall weakness is required to identify biomarkers and therapeutic targets that could improve patient management. Here, we summarize the current understanding of the genetically determined mechanisms underlying inherited aortopathies and critically appraise the available blood biomarkers, imaging techniques, and therapeutic targets that have shown promise for improving the management of patients with these important and potentially fatal conditions.

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<![CDATA[Effect of Cognitive Reserve on Risk of Cognitive Impairment and Recovery After Stroke]]> https://www.researchpad.co/article/N72226c51-9f7f-4a07-af9f-c2ce3166061c

Supplemental Digital Content is available in the text.

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<![CDATA[Does Chronic Kidney Disease Predict Stroke Risk Independent of Blood Pressure?]]> https://www.researchpad.co/article/N644a0641-f7b6-4dac-9337-bfa07a684c3b

Supplemental Digital Content is available in the text.

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<![CDATA[Blood Pressure and Risk of Subarachnoid Hemorrhage in China]]> https://www.researchpad.co/article/5c4b8fbfd5eed0c48487161f

Background and Purpose—

Subarachnoid hemorrhage (SAH) has a high case fatality rate and young mean age at onset compared with other types of stroke, but the pathogenesis of SAH is not fully understood. We examined associations of systolic and diastolic blood pressure with incident nontraumatic SAH in a large prospective study in China.

Methods—

In 2004 to 2008, 512 891 adults (59% women) from the general population were recruited into the CKB study (China Kadoorie Biobank). Participants were interviewed, measured, and followed up for fatal and nonfatal events. After excluding those with prior vascular disease, Cox regression analysis was used to relate blood pressure to incident SAH events. Analyses were adjusted for major confounders and corrected for regression dilution to give associations with long-term average blood pressure.

Results—

At baseline, mean age was 51 (SD, 11) years, and mean systolic blood pressure/diastolic blood pressure was 130.6/77.6 (SD, 21.0/11.1) mm Hg. During 3.5 million person-years of follow-up, there were 553 incident SAH cases (mean age at event, 61 [SD, 11] years), yielding an overall annual incidence rate of 12.9 per 100 000. Higher average levels of blood pressure were linearly and positively associated with higher risks of incident SAH: a 10 mm Hg higher systolic blood pressure and a 5 mm Hg higher diastolic blood pressure were associated with hazard ratios for SAH of 1.21 (95% CI, 1.13–1.29) and 1.20 (95% CI, 1.12–1.28), respectively. There was no evidence that the hazard ratios varied by age or sex or by levels of other vascular risk factors. Elevated blood pressure (systolic blood pressure, >120 mm Hg) accounted for 23% of all SAH cases.

Conclusions—

The incidence of SAH in China was comparable with estimates from Western populations. Higher levels of blood pressure were positively associated with higher risks of SAH, and elevated blood pressure accounted for about a quarter of all SAH cases.

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<![CDATA[Association Between Ambient Air Pollution and Cardiac Morpho-Functional Phenotypes]]> https://www.researchpad.co/article/5c184519d5eed0c4847fa65c

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<![CDATA[External Validation of Risk Scores for Major Bleeding in a Population-Based Cohort of Transient Ischemic Attack and Ischemic Stroke Patients]]> https://www.researchpad.co/article/5bfaa653d5eed0c48473a5f3

Supplemental Digital Content is available in the text.

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