ResearchPad - 10084 https://www.researchpad.co Default RSS Feed en-us © 2020 Newgen KnowledgeWorks <![CDATA[Inherited Thoracic Aortic Disease]]> https://www.researchpad.co/article/elastic_article_8313 Inherited thoracic aortopathies denote a group of congenital conditions that predispose to disease of the thoracic aorta. Aortic wall weakness and abnormal aortic hemodynamic profiles predispose these patients to dilatation of the thoracic aorta, which is generally silent but can precipitate aortic dissection or rupture with devastating and often fatal consequences. Current strategies to assess the future risk of aortic dissection or rupture are based primarily on monitoring aortic diameter. However, diameter alone is a poor predictor of risk, with many patients experiencing dissection or rupture below current intervention thresholds. Developing tools that improve the risk assessment of those with aortopathy is internationally regarded as a research priority. A robust understanding of the molecular pathways that lead to aortic wall weakness is required to identify biomarkers and therapeutic targets that could improve patient management. Here, we summarize the current understanding of the genetically determined mechanisms underlying inherited aortopathies and critically appraise the available blood biomarkers, imaging techniques, and therapeutic targets that have shown promise for improving the management of patients with these important and potentially fatal conditions.

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<![CDATA[Evaluating the Clinical Validity of Hypertrophic Cardiomyopathy Genes]]> https://www.researchpad.co/article/5c973e52d5eed0c48496b4c7

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<![CDATA[Metabolomic Consequences of Genetic Inhibition of PCSK9 Compared With Statin Treatment]]> https://www.researchpad.co/article/5c94e6d7d5eed0c4846533ee

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<![CDATA[Encephalopathy in a Large Cohort of British Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy Patients]]> https://www.researchpad.co/article/5c800fa1d5eed0c484a9620e

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<![CDATA[Influence of a Coronary Artery Disease‚ÄďAssociated Genetic Variant on FURIN Expression and Effect of Furin on Macrophage Behavior]]> https://www.researchpad.co/article/5c0c8573d5eed0c484963aeb

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