ResearchPad - 10173 https://www.researchpad.co Default RSS Feed en-us © 2020 Newgen KnowledgeWorks <![CDATA[Endovascular Therapy for Patients With Acute Ischemic Stroke During the COVID-19 Pandemic: A Proposed Algorithm]]> https://www.researchpad.co/article/N88feb4c6-7b47-4f51-b29f-d7e84105fbd7 <![CDATA[Effect of Cognitive Reserve on Risk of Cognitive Impairment and Recovery After Stroke]]> https://www.researchpad.co/article/N72226c51-9f7f-4a07-af9f-c2ce3166061c

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<![CDATA[Global Burden of Small Vessel Disease–Related Brain Changes on MRI Predicts Cognitive and Functional Decline]]> https://www.researchpad.co/article/N16bce7f2-3211-4e33-9877-fc3482076bce

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<![CDATA[Observer Agreement on Computed Tomography Perfusion Imaging in Acute Ischemic Stroke]]> https://www.researchpad.co/article/Nd6a2b2c5-56e8-4d2e-a201-2dd1dbfafa8b

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<![CDATA[Prehospital Transdermal Glyceryl Trinitrate for Ultra-Acute Intracerebral Hemorrhage]]> https://www.researchpad.co/article/Nbe5cbd37-481d-479c-9c18-a47ec70095a7

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<![CDATA[Does Chronic Kidney Disease Predict Stroke Risk Independent of Blood Pressure?]]> https://www.researchpad.co/article/N644a0641-f7b6-4dac-9337-bfa07a684c3b

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<![CDATA[Fine-Tuning of Sox17 and Canonical Wnt Coordinates the Permeability Properties of the Blood-Brain Barrier]]> https://www.researchpad.co/article/5c973c4ed5eed0c484968484

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<![CDATA[Effectiveness and Safety of Oral Anticoagulants Among Nonvalvular Atrial Fibrillation Patients]]> https://www.researchpad.co/article/5c94e6ecd5eed0c48465361d

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<![CDATA[Intracranial Carotid Artery Calcification and Effect of Endovascular Stroke Treatment]]> https://www.researchpad.co/article/5c94e6ead5eed0c4846535df

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<![CDATA[Effect of Glyceryl Trinitrate on Hemodynamics in Acute Stroke]]> https://www.researchpad.co/article/5c800fc2d5eed0c484a9651c

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<![CDATA[Endovascular Treatment]]> https://www.researchpad.co/article/5c800faad5eed0c484a96323

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<![CDATA[Encephalopathy in a Large Cohort of British Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy Patients]]> https://www.researchpad.co/article/5c800fa1d5eed0c484a9620e

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<![CDATA[Canagliflozin and Stroke in Type 2 Diabetes Mellitus]]> https://www.researchpad.co/article/5c800fb0d5eed0c484a963a1

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<![CDATA[Higher Pulsatility in Cerebral Perforating Arteries in Patients With Small Vessel Disease Related Stroke, a 7T MRI Study]]> https://www.researchpad.co/article/5c4b8fc5d5eed0c484871718

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<![CDATA[Time Trends in Atrial Fibrillation-Associated Stroke and Premorbid Anticoagulation]]> https://www.researchpad.co/article/5c4b8fced5eed0c484871864

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<![CDATA[Genetically Determined Platelet Count and Risk of Cardiovascular Disease]]> https://www.researchpad.co/article/5c1844c8d5eed0c4847f9887

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<![CDATA[Genetic Study of White Matter Integrity in UK Biobank (N=8448) and the Overlap With Stroke, Depression, and Dementia]]> https://www.researchpad.co/article/5c032122d5eed0c4844e7769

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<![CDATA[NOR-SASS (Norwegian Sonothrombolysis in Acute Stroke Study)]]> https://www.researchpad.co/article/5b365c45463d7e5448d9f699

Background and Purpose—

The NOR-SASS (Norwegian Sonothrombolysis in Acute Stroke Study) aimed to assess effect and safety of contrast-enhanced ultrasound treatment in an unselected acute ischemic stroke population.

Methods—

Patients treated with intravenous thrombolysis within 4.5 hours after symptom onset were randomized 1:1 to either contrast-enhanced sonothrombolysis (CEST) or sham CEST. A visible arterial occlusion on baseline computed tomography angiography was not a prerequisite for inclusion. Pulse-wave 2 MHz ultrasound was given for 1 hour and contrast (SonoVue) as an infusion for ≈30 minutes. Magnetic resonance imaging and angiography were performed after 24 to 36 hours. Primary study end points were neurological improvement at 24 hours defined as National Institutes of Health Stroke Scale score 0 or reduction of ≥4 National Institutes of Health Stroke Scale points compared with baseline National Institutes of Health Stroke Scale and favorable functional outcome at 90 days defined as modified Rankin scale score 0 to 1.

Results—

A total of 183 patients were randomly assigned to either CEST (93 patient) or sham CEST (90 patients). The rates of symptomatic intracerebral hemorrhage, asymptomatic intracerebral hemorrhage, or mortality were not increased in the CEST group. Neurological improvement at 24 hours and functional outcome at 90 days was similar in the 2 groups both in the intention-to-treat analysis and in the per-protocol analysis.

Conclusions—

CEST is safe among unselected ischemic stroke patients with or without a visible occlusion on computed tomography angiography and with varying grades of clinical severity. There was, however, statistically no significant clinical effect of sonothrombolysis in this prematurely stopped trial.

Clinical Trial Registration—

URL: http://www.clinicaltrials.gov. Unique identifier: NCT01949961.

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<![CDATA[Long-Term Survival After Intravenous Thrombolysis for Ischemic Stroke]]> https://www.researchpad.co/article/5bfaa64fd5eed0c48473a53f

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