ResearchPad - 307 https://www.researchpad.co Default RSS Feed en-us © 2020 Newgen KnowledgeWorks <![CDATA[Primary prostate cancer educates bone stroma through exosomal pyruvate kinase M2 to promote bone metastasis]]> https://www.researchpad.co/article/elastic_article_15295

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<![CDATA[From blood development to disease: a paradigm for clinical translation]]> https://www.researchpad.co/article/N734ce265-e3e2-4753-b1d6-4e794000dc65

ABSTRACT

Translating basic research to the clinic is a primary aim of Disease Models & Mechanisms, and the recent successes in hematopoiesis research provide a blueprint of how fundamental biological research can provide solutions to important clinical problems. These advances were the main motivation for choosing hematopoiesis disorders as the focus of our inaugural meeting, ‘Blood Disorders: Models, Mechanisms and Therapies’, which was held in early October 2019. This Editorial discusses the reasons for and the challenges of interdisciplinary research in hematopoiesis, provides examples of how research in model systems is a key translational step towards effective treatments for blood disorders and summarizes what the community believes are the key exciting developments and challenges in this field.

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<![CDATA[Genome-scale CRISPR-Cas9 screen identifies druggable dependencies in TP53 wild-type Ewing sarcoma]]> https://www.researchpad.co/article/5c69ecb6d5eed0c48414e227

Stolte et al. use genome-scale CRISPR-Cas9 screening technology to identify druggable targets for TP53 wild-type Ewing sarcoma and discover reactivation of p53 through inhibition of MDM2, MDM4, Wip1, or USP7 as therapeutic strategies for the disease.

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