ResearchPad - 314 https://www.researchpad.co Default RSS Feed en-us © 2020 Newgen KnowledgeWorks <![CDATA[Selective inhibition of low-affinity memory CD8<sup>+</sup> T cells by corticosteroids]]> https://www.researchpad.co/article/elastic_article_15298

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<![CDATA[Identification of non-mutated neoantigens presented by TAP-deficient tumors]]> https://www.researchpad.co/article/5c91078fd5eed0c4841a44f0

A hybrid forward-reversed immunological screen is performed to identify 16 novel HLA-A2 presented cancer antigens. These peptides are selectively presented by immune-escaped cancer cells with defects in the peptide transporter TAP. In contrast to mutated neoantigens, these “self” neoantigens are universally presented across different cancer types.

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<![CDATA[Metabolic control of regulatory T cell stability and function by TRAF3IP3 at the lysosome]]> https://www.researchpad.co/article/5c91079cd5eed0c4841a4638

Metabolic programs are crucial for T reg cell stability and function. Yu et al. report that TRAF3IP3 acts as a pivotal regulator in controlling metabolic fitness to maintain T reg cell stability and function at the lysosome.

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<![CDATA[Activated CARD11 accelerates germinal center kinetics, promoting mTORC1 and terminal differentiation]]> https://www.researchpad.co/article/5c910784d5eed0c4841a4402

B cell–intrinsic activated CARD11 (aCARD11) expression promotes rapid formation and premature collapse of the germinal center while enhancing terminal differentiation due to heightened NF-κB and mTORC1 signaling.

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<![CDATA[Transcription factor Etv6 regulates functional differentiation of cross-presenting classical dendritic cells]]> https://www.researchpad.co/article/5c910798d5eed0c4841a45bb

Transcriptional control of dendritic cell (DC) functions is poorly understood. Lau, Tiniakou, et al. report that transcription factor ETV6 optimizes gene expression in DCs and facilitates their ability to cross-prime T cells and initiate tumor-specific immune responses.

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<![CDATA[Specifically differentiated T cell subset promotes tumor immunity over fatal immunity]]> https://www.researchpad.co/article/5c01f8cbd5eed0c4842bec4f

Ramadan et al. demonstrate that triggering the ST2–IL-33 pathway in IL-9–secreting T cells decreases the severity of graft-versus-host disease through AREG upregulation while maintaining graft versus leukemia activity by preserving the central memory phenotype of CD8, increasing CD8α and cytolytic molecule expression.

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<![CDATA[The methyltransferase NSD3 promotes antiviral innate immunity via direct lysine methylation of IRF3]]> https://www.researchpad.co/article/5c01f8ddd5eed0c4842bf02c

Wang et al. demonstrate that methyltransferase NSD3 directly methylates IRF3 and maintains IRF3 phosphorylation to enhance its transcriptional activity by disassociating the methylated IRF3 and PP1cc to prevent IRF3 dephosphorylation, consequently promoting antiviral innate immune response.

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<![CDATA[A nonimmune function of T cells in promoting lung tumor progression]]> https://www.researchpad.co/article/5c01f8cfd5eed0c4842bed02

Green et al. find that T cell–derived amphiregulin facilitates lung tumor progression seemingly independently of the immune response, suggesting that T cells can promote tumor growth through the production of factors normally associated with tissue repair.

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