ResearchPad - 315 https://www.researchpad.co Default RSS Feed en-us © 2020 Newgen KnowledgeWorks <![CDATA[A novel disorder involving dyshematopoiesis, inflammation, and HLH due to aberrant CDC42 function]]> https://www.researchpad.co/article/elastic_article_15293

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<![CDATA[miR-196b target screen reveals mechanisms maintaining leukemia stemness with therapeutic potential]]> https://www.researchpad.co/article/5c69ecb1d5eed0c48414e18f

Through functional screening of a miR-196b target network in the poor prognosis subgroup of MLL-rearranged AML, Meyer et al. reveal a therapeutically targetable Skp2/p27Kip1 regulatory axis that modulates leukemic stemness, differentiation, and survival.

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<![CDATA[Dissection of progenitor compartments resolves developmental trajectories in B-lymphopoiesis]]> https://www.researchpad.co/article/5c368397d5eed0c4841f437a

Jensen et al. report the identification and characterization of novel lymphoid progenitor populations in the mouse bone marrow. The work resolves the complexity of the BLP/pre-pro–B/Fraction A compartments and provides a developmental trajectory for early B cell development.

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<![CDATA[Identification and characterization of T reg–like cells in zebrafish]]> https://www.researchpad.co/article/5c01f8c7d5eed0c4842beb82

Kasheta et al. report the identification of T reg–like cells in zebrafish, a means to track and live-image these cells, and foxp3a-deficient mutants that display lymphoproliferation, severe inflammation, and other hallmarks of T reg deficiency syndromes.

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