ResearchPad - comment https://www.researchpad.co Default RSS Feed en-us © 2020 Newgen KnowledgeWorks <![CDATA[Covid-19 and the need for perinatal mental health professionals: now more than ever before]]> https://www.researchpad.co/article/elastic_article_11110 <![CDATA[Risk-Stratifying COVID-19 Patients the Right Way<a href="#fn1">∗</a>]]> https://www.researchpad.co/article/elastic_article_11073 <![CDATA[Low-tech solutions for the COVID-19 supply chain crisis]]> https://www.researchpad.co/article/elastic_article_10325 A global effort is ongoing in the scientific community and in the maker movement, which focuses on creating devices and tinkering with them, to reverse-engineer commercial medical equipment and get it to healthcare workers. For these ‘low-tech’ solutions to have a real impact, it is important for them to coalesce around approved designs.

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<![CDATA[BCG-induced trained immunity: can it offer protection against COVID-19?]]> https://www.researchpad.co/article/elastic_article_10323 Could the BCG vaccine be used to bridge the gap until a specific COVID-19 vaccine is developed? Luke O’Neill and Mihai Netea discuss the science behind this approach.

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<![CDATA[A retrospective on lithium-ion batteries]]> https://www.researchpad.co/article/elastic_article_9768 The 2019 Nobel Prize in Chemistry has been awarded to John B. Goodenough, M. Stanley Whittingham and Akira Yoshino for their contributions in the development of lithium-ion batteries, a technology that has revolutionized our way of life. Here we look back at the milestone discoveries that have shaped the modern lithium-ion batteries for inspirational insights to guide future breakthroughs.

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<![CDATA[COVID19 and ophthalmology: a brief summary of the literature]]> https://www.researchpad.co/article/elastic_article_9378 <![CDATA[Efficacy of slit lamp breath shields]]> https://www.researchpad.co/article/elastic_article_9371 <![CDATA[Oculoplastic video-based telemedicine consultations: Covid-19 and beyond]]> https://www.researchpad.co/article/elastic_article_9342 <![CDATA[Personal protective equipment (PPE) for vitreoretinal surgery during COVID-19]]> https://www.researchpad.co/article/elastic_article_9325 <![CDATA[PIK3C3/VPS34 links T-cell autophagy to autoimmunity]]> https://www.researchpad.co/article/elastic_article_8894 <![CDATA[Chatbots in the fight against the COVID-19 pandemic]]> https://www.researchpad.co/article/Na66515ef-ec9d-49bf-81a2-8eb23a1a3178 We are all together in a fight against the COVID-19 pandemic. Chatbots, if effectively designed and deployed, could help us by sharing up-to-date information quickly, encouraging desired health impacting behaviors, and lessening the psychological damage caused by fear and isolation. Despite this potential, the risk of amplifying misinformation and the lack of prior effectiveness research is cause for concern. Immediate collaborations between healthcare workers, companies, academics and governments are merited and may aid future pandemic preparedness efforts.

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<![CDATA[Avoiding collateral mortality in a pandemic — time to change our mindset in surgical oncology]]> https://www.researchpad.co/article/N73a41835-d067-436e-9c18-f610b61328d1 The coronavirus disease 19 (COVID-19) pandemic has become the focus of attention worldwide, and herein we seek to highlight the potential problem of ‘collateral mortality’ from delayed or deferred treatments in patients with cancer. We propose potential solutions to ensure continuity of care in the field of surgical oncology.

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<![CDATA[Drug repurposing in cardiology]]> https://www.researchpad.co/article/Nff53d4b0-047c-4d43-8443-eedc22b61f57 <![CDATA[Pontin/Tip49 acts as a novel regulator of JNK pathway]]> https://www.researchpad.co/article/N2612489e-67fe-430f-8847-96c2df3bde28 <![CDATA[Mitochondrial DNA keeps you young]]> https://www.researchpad.co/article/Nb9859dc0-f293-4c34-815f-23a88a133d95 <![CDATA[BTK: a two-faced effector in cancer and tumour suppression]]> https://www.researchpad.co/article/N5b0eeb1e-cffe-4e44-8391-fd1c34d8edd1 Many genes of the human genome display pleiotropic activity, playing an important role in two or more unrelated pathways. Surprisingly, some of these functions can even be antagonistic, often letting to divergent functional outcomes depending on microenviromental cues and tissue/cell type-dependent parameters. Lately, the Bruton’s tyrosine kinase (BTK) has emerged as one of such pleiotropic genes, with opposing effects in cancer pathways. While it has long been considered oncogenic in the context of B cell malignancies, recent data shows that BTK can also act as a tumour suppressor in other cells, as an essential member of the p53 and p73 responses to damage. Since BTK inhibitors are already being used clinically, it is important to carefully review these new findings in order to fully understand the consequences of blocking BTK activity in all the cells of the organism.

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<![CDATA[The Zen of XEN: insight into differentiation, metabolism and genomic integrity]]> https://www.researchpad.co/article/N2649cf6b-049d-4e7d-9306-30a653226fc8 <![CDATA[Inactivation of Lon protease reveals a link between mitochondrial unfolded protein stress and mitochondrial translation inhibition]]> https://www.researchpad.co/article/N24526ebb-75f6-4156-b7d0-3a3bba03dd37 The mitochondrial Unfolded Protein Response (UPRmt) pathway confers protection from misfolded and aggregated proteins by activating factors that promote protein folding and degradation. Our recent work on Lon protease, a member of the mitochondrial ATPase Associated with diverse cellular Activities (AAA+) family of mitochondrial resident proteases, suggests that mitochondrial translational inhibition may also be a feature of the UPRmt pathway.

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<![CDATA[CRISPR/Cas9 can mediate high-efficiency off-target mutations in mice in vivo]]> https://www.researchpad.co/article/N0c91839a-1f68-4ac3-abcf-2aef70d1146b <![CDATA[BAP1 regulates different mechanisms of cell death]]> https://www.researchpad.co/article/N1719f6a1-66c2-4938-bbfb-0b14e473f983