ResearchPad - expert-consensus https://www.researchpad.co Default RSS Feed en-us © 2020 Newgen KnowledgeWorks <![CDATA[中国埃克替尼治疗非小细胞肺癌专家共识(2015版)]]> https://www.researchpad.co/article/5c052b34d5eed0c4848a5a8f <![CDATA[热消融治疗原发性和转移性肺部肿瘤的专家共识(2014年版)]]> https://www.researchpad.co/article/5c052abcd5eed0c4848a4ad2 <![CDATA[抑癌基因<i>TCF21</i>对肺癌细胞A549增殖、凋亡和迁移的影响]]> https://www.researchpad.co/article/5c052abed5eed0c4848a4b2c 转录因子21(transcription factor 21, TCF21)是新近发现的抑癌基因,其在多种肿瘤中具有抑癌功能,本研究旨在探讨TCF21基因对人肺癌A549细胞增殖、迁移和凋亡的影响。方法利用慢病毒转染技术在肺癌A549细胞中高表达TCF21基因,以荧光定量PCR、Western blot分析目的基因的表达,并采用Transwell、MTT法、流式细胞术检测TCF21高表达对A549迁移、增殖、凋亡的影响。结果成功在肺癌细胞株A549中高表达TCF21,且高表达TCF21后A549的细胞生长和迁移能力受抑制、凋亡率增高。结论抑癌基因TCF21可抑制A549细胞的增殖和迁移、诱导凋亡。 ]]> <![CDATA[上海市肺科医院磨玻璃结节早期肺腺癌的诊疗共识(第一版)]]> https://www.researchpad.co/article/5c0528f3d5eed0c48489d941 随着胸部计算机断层扫描(computed tomography, CT)检查,尤其是低剂量薄层CT筛查项目在中国的广泛开展,越来越多的无症状肺部磨玻璃结节(ground-glass nodules, GGNs)被发现。虽然国内及国际上已发布了一系列针对肺部GGNs的指南,但是这些指南的撰写者多来自呼吸、肿瘤及影像专业,可能缺乏对现代微创胸外科的充分认识,造成外科手术在肺部GGNs诊治中的作用不明确,甚至被低估;而且,肺部肿瘤相关的各学科对于早期肺癌,尤其是浸润前病变的处理也缺乏统一规范。因此,基于国内外现有文献及上海市肺科医院多年积累的经验,上海市肺科医院撰写了此诊疗共识。本共识推荐对于疑似肺腺癌的GGNs进行多学科评估,依据诊断,选择合理的处置方式。对于疑似原位腺癌,推荐进行胸部薄层CT随访,或在特定情况下进行不超过肺段切除的限制性肺切除;对于疑似微浸润腺癌,推荐进行限制性肺切除或肺叶切除;对于疑似浸润性腺癌,建议依据病灶是否含有磨玻璃成分、位置、大小、个数及患者躯体情况选择合理的手术方式;而肺多发结节的处理原则推荐为主病灶优先,兼顾次要病灶,综合选择治疗方案。

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<![CDATA[中国埃克替尼治疗非小细胞肺癌专家共识(2016年版)]]> https://www.researchpad.co/article/5c0528b5d5eed0c48489c889 <![CDATA[Clinical expert consensus document on quantitative coronary angiography from the Japanese Association of Cardiovascular Intervention and Therapeutics]]> https://www.researchpad.co/article/Na8cb5ade-432e-4b7c-a023-180cbd4a17c9

Quantitative coronary angiography (QCA) remains to play an important role in clinical trials and post-marketing surveillance related to the safety and efficacy of new PCI devices. In this document, the current standard methodology of QCA is summarized. In addition, its history, recent development and future perspectives are also reviewed.

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<![CDATA[Lifetime cardiovascular management of patients with previous Kawasaki disease]]> https://www.researchpad.co/article/N0efd417f-be83-4583-a953-224961c88ea4

Kawasaki disease (KD) is an inflammatory disorder of young children, associated with vasculitis of the coronary arteries with subsequent aneurysm formation in up to one-third of untreated patients. Those who develop aneurysms are at life-long risk of coronary thrombosis or the development of stenotic lesions, which may lead to myocardial ischaemia, infarction or death. The incidence of KD is increasing worldwide, and in more economically developed countries, KD is now the most common cause of acquired heart disease in children. However, many clinicians in the UK are unaware of the disorder and its long-term cardiac complications, potentially leading to late diagnosis, delayed treatment and poorer outcomes. Increasing numbers of patients who suffered KD in childhood are transitioning to the care of adult services where there is significantly less awareness and experience of the condition than in paediatric services. The aim of this document is to provide guidance on the long-term management of patients who have vascular complications of KD and guidance on the emergency management of acute coronary complications. Guidance on the management of acute KD is published elsewhere.

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