ResearchPad - highlights https://www.researchpad.co Default RSS Feed en-us © 2020 Newgen KnowledgeWorks <![CDATA[Clinical Trial Highlights – GLP-1 agonists]]> https://www.researchpad.co/article/elastic_article_10110 <![CDATA[Mediterranean Journal of Rheumatology December 2019 Highlights]]> https://www.researchpad.co/article/elastic_article_10017 <![CDATA[Soluble pattern recognition molecules: Guardians and regulators of homeostasis at airway mucosal surfaces]]> https://www.researchpad.co/article/elastic_article_6907 Airway epithelial cells actively contribute to protection of the respiratory tract, by locally secreting soluble pattern recognition receptors (sPRR). The sPRR play critical roles in the recognition of conserved motifs and are linked to complement activation. This article reviews the current knowledge on the involvement of sPRRs in the pathogenesis of allergic airway diseases.

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<![CDATA[立体定向消融体部放射治疗早期可手术Ⅰ期非小细胞肺癌—距离常规应用有多远?]]> https://www.researchpad.co/article/5c052b2ed5eed0c4848a59f8 <![CDATA[Ⅰ期非小细胞肺癌的治疗:立体定向放疗能替代外科手术?]]> https://www.researchpad.co/article/5c052a65d5eed0c4848a3747 <![CDATA[Stereotactic Ablative Radiotherapy versus Lobectomy for Operable Stage I Non-small-cell Lung Cancer: A Pooled Analysis of Two Randomized Trials——胸外科医生的解读]]> https://www.researchpad.co/article/5c052a62d5eed0c4848a35c2 <![CDATA[Editors' selection of papers from China's academic journals]]> https://www.researchpad.co/article/N3a1c4190-86c5-44e6-977e-79c6ef49ac29 ]]> <![CDATA[ERS International Congress, Madrid, 2019: highlights from the Basic and Translational Science Assembly]]> https://www.researchpad.co/article/Nf2211aea-35d3-4e6f-892a-97256fe90cde

In this review, the Basic and Translational Sciences Assembly of the European Respiratory Society (ERS) provides an overview of the 2019 ERS International Congress highlights. In particular, we discuss how the novel and very promising technology of single cell sequencing has led to the development of a comprehensive map of the human lung, the lung cell atlas, including the discovery of novel cell types and new insights into cellular trajectories in lung health and disease. Further, we summarise recent insights in the field of respiratory infections, which can aid in a better understanding of the molecular mechanisms underlying these infections in order to develop novel vaccines and improved treatment options. Novel concepts delineating the early origins of lung disease are focused on the effects of pre- and post-natal exposures on neonatal lung development and long-term lung health. Moreover, we discuss how these early life exposures can affect the lung microbiome and respiratory infections. In addition, the importance of metabolomics and mitochondrial function analysis to subphenotype chronic lung disease patients according to their metabolic program is described. Finally, basic and translational respiratory science is rapidly moving forward and this will be beneficial for an advanced molecular understanding of the mechanisms underlying a variety of lung diseases. In the long-term this will aid in the development of novel therapeutic targeting strategies in the field of respiratory medicine.

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<![CDATA[Highlight—Blind as a Bat? The Genetic Basis of Echolocation in Bats and Whales]]> https://www.researchpad.co/article/N8aa10602-81f5-4f40-aeaf-56dab40a4a2a ]]> <![CDATA[Molecular Detection of Biological Agents in the Field: Then and Now]]> https://www.researchpad.co/article/Nae0c752a-5659-411d-b799-25dd07feb86e

Molecular detection of biological agents in the field has traditionally relied on the use of quantitative real-time PCR (qPCR), which now includes commercially available instruments that can be used in the laboratory or field. Adapting this technology for field-forward applications necessitated innovation to minimize size, weight, and power requirements.

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<![CDATA[Unique neurobiology during the sensitive period for attachment produces distinctive infant trauma processing]]> https://www.researchpad.co/article/5b22d19a463d7e603633dbde

Background

Trauma has neurobehavioral effects when experienced at any stage of development, but trauma experienced in early life has unique neurobehavioral outcomes related to later life psychiatric sequelae. Recent evidence has further highlighted the context of infant trauma as a critical variable in determining its immediate and enduring consequences. Trauma experienced from an attachment figure, such as occurs in cases of caregiver child maltreatment, is particularly detrimental.

Methods

Using data primarily from rodent models, we review the literature on the interaction between trauma and attachment in early life, which highlights the role of the caregiver’s presence in engagement of attachment brain circuitry and suppressing threat processing by the amygdala. We then consider how trauma with and without the caregiver produces long-term changes in emotionality and behavior, and suggest that these experiences initiate distinct pathways to pathology.

Results

Together these data suggest that infant trauma processing and its enduring effects are impacted by both the immaturity of brain areas for processing trauma and the unique functioning of the early-life brain, which is biased toward processing information within the attachment circuitry.

Conclusion

An understanding of developmental differences in trauma processing as well as the critical role of the caregiver in further altering early life brain processing of trauma is important for developing age-relevant treatment and interventions.

Highlights of this article

  • Trauma experienced in early life has been linked with life-long outcomes for mental health through a mechanism that remains unclear.

  • Trauma experienced in the presence of a caregiver has unique consequences.

  • The infant brain is predisposed toward processing information using attachment circuitry rather than threat circuitry.

  • Data from rodent models suggest that repeated trauma in the presence of a caregiver prematurely engages brain areas important for threat, which may play a role in deleterious outcome.

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<![CDATA[Draft genome sequence of Acinetobacter pittii ST643 shared by cystic fibrosis patients]]> https://www.researchpad.co/article/5b03113f463d7e6289a542b8

Acinetobacter pittii has emerged as an important hospital pathogen that is associated with outbreaks and drug resistance. In cystic fibrosis (CF) patients, the detection of Acinetobacter spp. is rare; however, we isolated the A. pittii sequence type ST643 in several Brazilian CF patients treated in the same centre. The current study describes the draft genome of A. pittii ST643.

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<![CDATA[In Search of Autism’s Roots]]> https://www.researchpad.co/article/5989da24ab0ee8fa60b80050 ]]> <![CDATA[Living Life on a Magnet]]> https://www.researchpad.co/article/5989db39ab0ee8fa60bd44b4 ]]> <![CDATA[An appetite for understanding appetite]]> https://www.researchpad.co/article/5989db5cab0ee8fa60be0395 ]]> <![CDATA[A Swarm of Bee Research]]> https://www.researchpad.co/article/5989db54ab0ee8fa60bdd064 ]]> <![CDATA[p53-induced inflammation links heart failure with insulin resistance]]> https://www.researchpad.co/article/5ac1fbdd463d7e4d499fe653 ]]> <![CDATA[Research Highlights]]> https://www.researchpad.co/article/5989daf1ab0ee8fa60bc1257 ]]> <![CDATA[CF-related diabetes: new insights from ferrets]]> https://www.researchpad.co/article/5ac6f42a463d7e4269dcce8d ]]> <![CDATA[Highlight—Making It Big: Salamanders Keep DNA Near and Dear]]> https://www.researchpad.co/article/5ac8e034463d7e5f17b8bb10 ]]>