ResearchPad - neuronal-plasticity-behavior Default RSS Feed en-us © 2020 Newgen KnowledgeWorks <![CDATA[Hippocampal long‐term synaptic depression and memory deficits induced in early amyloidopathy are prevented by enhancing G‐protein‐gated inwardly rectifying potassium channel activity]]> Disruption of hippocampal synaptic plasticity by amyloid‐β (Aβ) peptides is thought to be responsible for learning and memory impairments in early Alzheimer's disease. Here we describe an Aβ‐mediated deleterious synaptic mechanism that modifies the threshold for the induction of hippocampal LTP and/or LTD and underlies memory alterations in amyloidosis models. We also propose a potential intervention to prevent such synaptic impairment through G‐protein‐gated inwardly rectifying potassium (GirK) channels activation.