ResearchPad - research-article-‐-fundamental https://www.researchpad.co Default RSS Feed en-us © 2020 Newgen KnowledgeWorks <![CDATA[Lateral induction limits the impact of cell connectivity on Notch signaling in arterial walls]]> https://www.researchpad.co/article/elastic_article_6951 Notch, a mechanosensitive signaling pathway, is one of the main regulators of the phenotype of vascular smooth muscle cells, the mediators of arterial growth and remodeling. Here, we extended a recent one‐dimensional agent‐based model for Notch signaling in arteries to a two‐dimensional formulation to investigate the effects of the number of cell neighbors on Notch dynamics. The simulations indicate that Notch lateral induction ensures a stability of Notch dynamics with respect to variations of the numbers of cell neighbors.

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<![CDATA[Computational instantaneous wave‐free ratio (IFR) for patient‐specific coronary artery stenoses using 1D network models]]> https://www.researchpad.co/article/N23dcba9a-bbe7-4073-8e57-163721bba11a

Abstract

In this work, we estimate the diagnostic threshold of the instantaneous wave‐free ratio (iFR) through the use of a one‐dimensional haemodynamic framework. To this end, we first compared the computed fractional flow reserve (cFFR) predicted from a 1D computational framework with invasive clinical measurements. The framework shows excellent promise and utilises minimal patient data from a cohort of 52 patients with a total of 66 stenoses. The diagnostic accuracy of the cFFR model was 75.76%, with a sensitivity of 71.43%, a specificity of 77.78%, a positive predictive value of 60%, and a negative predictive value of 85.37%. The validated model was then used to estimate the diagnostic threshold of iFR. The model determined a quadratic relationship between cFFR and the ciFR. The iFR diagnostic threshold was determined to be 0.8910 from a receiver operating characteristic curve that is in the range of 0.89 to 0.9 that is normally reported in clinical studies.

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