ResearchPad - research-letter https://www.researchpad.co Default RSS Feed en-us © 2020 Newgen KnowledgeWorks <![CDATA[Delivery for respiratory compromise among pregnant women with coronavirus disease 2019]]> https://www.researchpad.co/article/elastic_article_13685 <![CDATA[Coronavirus Disease 2019 Infection Among Medical Staff in Wuhan]]> https://www.researchpad.co/article/elastic_article_13677 <![CDATA[COVID-19 infection also occurs in patients taking hydroxychloroquine]]> https://www.researchpad.co/article/elastic_article_12365 <![CDATA[Favipiravir, an antiviral for COVID-19?]]> https://www.researchpad.co/article/elastic_article_12348 <![CDATA[Angiotension-converting enzyme inhibitors and angiotensin-receptor blockers are not associated with increased risk of SARS-CoV-2 infection]]> https://www.researchpad.co/article/elastic_article_12307 In a large Israeli dataset of 14 520 individuals tested for SARS-CoV-2, angiotension-converting enzyme inhibitors and angiotensin-receptor blockers were not found to be associated with increased SARS-CoV-2 infection after adjusting for major confounders. Patients on these medications should not stop their medication prophylactically.

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<![CDATA[Lopinavir/ritonavir in COVID-19 patients: maybe yes, but at what dose?]]> https://www.researchpad.co/article/elastic_article_12291 <![CDATA[Prone positioning combined with high-flow nasal or conventional oxygen therapy in severe Covid-19 patients]]> https://www.researchpad.co/article/elastic_article_10689 <![CDATA[Two consecutive myocardial tissue insults for inpatients with COVID-19]]> https://www.researchpad.co/article/elastic_article_10667 <![CDATA[COVID-19 patients exhibit less pronounced immune suppression compared with bacterial septic shock patients]]> https://www.researchpad.co/article/elastic_article_10653 <![CDATA[Uropathologists During the COVID-19 Pandemic: What Can Be Learned in Terms of Social Interaction, Visibility, and Social Distance]]> https://www.researchpad.co/article/elastic_article_10331 <![CDATA[Downregulation of miR-637 promotes vascular smooth muscle cell proliferation and migration via regulation of insulin-like growth factor-2]]> https://www.researchpad.co/article/elastic_article_9736 Dysregulation of the proliferation and migration of vascular smooth muscle cells (VSMCs) is a crucial cause of atherosclerosis. MiR-637 exerts an antiproliferative effect on multiple human cells. Its impact on atherosclerosis remains largely unexplored.MethodsReal-time PCR was used to determine miR-637 expression in samples from atherosclerosis patients and animal models. Its expression in VSMC dysfunction models (induced by ox-LDL) was also measured. The proliferation and migration of VSMCs were respectively tested using CCK-8 and Transwell assays, and apoptosis was measured using flow cytometry. The Targetscan database was used to predict the target genes of miR-637. Interaction between miR-637 and the potential target gene was validated via real-time PCR, western blotting and a luciferase reporter assay.ResultsMiR-637 expression was significantly lower in atherosclerosis patient and animal model samples. It also decreased in a dose- and time-dependent manner in animal models with ox-LDL-induced atherosclerosis. Transfection with miR-637 mimics suppressed the proliferation and migration of VSMCs while promoting apoptosis, while transfection with miR-637 inhibitors had the opposite effects. We also validated that insulin-like growth factor-2 (IGF-2), a crucial factor in the pathogenesis of atherosclerosis, serves as a target gene for miR-637.ConclusionMiR-637 targeting IGF-2 contributes to atherosclerosis inhibition and could be a potential target for this disease. ]]> <![CDATA[Bedside ultrasound measurement of optic nerve sheath diameter in patients with sepsis: a prospective observational study]]> https://www.researchpad.co/article/elastic_article_9444 <![CDATA[Simultaneous ventilation of two simulated ARDS patients in COVID-19 pandemic]]> https://www.researchpad.co/article/elastic_article_9440 <![CDATA[Mesenchymal Stromal Cell–Derived Exosomes Contribute to Epithelial Regeneration in Experimental Inflammatory Bowel Disease]]> https://www.researchpad.co/article/elastic_article_6237 <![CDATA[Large Deletions in <i>GANAB</i> and <i>SEC63</i> Explain 2 Cases of Polycystic Kidney and Liver Disease]]> https://www.researchpad.co/article/elastic_article_5946 <![CDATA[Ritonavir-Boosted Protease Inhibitors Do Not Significantly Affect the Performance of Creatinine-Based Estimates of GFR]]> https://www.researchpad.co/article/elastic_article_5911 <![CDATA[Use of triiodothyronine to treat critically ill COVID-19 patients: a new clinical trial]]> https://www.researchpad.co/article/N31ff8389-5dc7-4ea7-b931-9b749668899b <![CDATA[Association of Adjuvant Chemotherapy With Overall Survival in Patients With Early-Stage Breast Cancer and 21-Gene Recurrence Scores of 26 or Higher]]> https://www.researchpad.co/article/Nba4f4c0a-8488-46f6-9aba-327b7280fa82 This cohort study investigates the association of overall survival with receiving chemotherapy among patients with early-stage breast cancer and recurrence scores of 26 to 30 vs those with recurrence scores of 31 or greater.

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<![CDATA[Intensive care for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in a makeshift ICU in Wuhan]]> https://www.researchpad.co/article/N225f4f47-ce56-4dd3-8f34-0b9eb6bb5d5d <![CDATA[Concordance Between Electronic Health Record Data and Medicare Part D Claims Data for Oral Anticancer Drug Use]]> https://www.researchpad.co/article/N1471ba53-b3db-456b-a586-1aa1e4fa1a49 This cross-sectional study determines the concordance between electronic health record and Medicare Part D claims data for the receipt of oral anticancer agents.

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