ResearchPad - review-series:-barrier-immunity https://www.researchpad.co Default RSS Feed en-us © 2020 Newgen KnowledgeWorks <![CDATA[The developing immune network in human prenatal skin]]> https://www.researchpad.co/article/elastic_article_7954 The immune system in skin is established early during development. Throughout development it continues to expand and diversify.

]]>
<![CDATA[Respiratory microbiome and epithelial interactions shape immunity in the lungs]]> https://www.researchpad.co/article/elastic_article_7951 The respiratory epithelium provides a highly effective barrier acting as the first line of defence against potentially harmful environmental stimuli including microbes and allergens.

]]>
<![CDATA[Regulation of barrier immunity and homeostasis by integrin‐mediated transforming growth factor <i>β</i> activation]]> https://www.researchpad.co/article/elastic_article_7950 TGF‐β is a crucial cytokine in regulation of the immune system, especially at barrier sites. Many cell types can produce TGF‐β, but always as an inactive complex that requires activating to be functional. This review highlights vital pathways that activate TGF‐β in the intestine, lung and skin, with a focus on how integrins control TGF‐β activity in a context‐specific manner.

]]>
<![CDATA[Immunological fortification at our barrier organs: Protecting us as we age]]> https://www.researchpad.co/article/elastic_article_7948 Our barrier surfaces are fundamental in protecting us from the outside world and segregating key biological processes. The immunological fortifications found at these sites therefore possess many distinct qualities, which are discussed in Immunology's series of reviews on Barrier Immunity. Together these reviews showcase novel biological processes identified through the use of state‐of‐the‐art technologies, and specifically highlight how these change throughout our lives.

]]>
<![CDATA[The liver as an immunological barrier redefined by single‐cell analysis]]> https://www.researchpad.co/article/elastic_article_7947 The liver is a front‐line immune tissue that plays a major role in the detection, capture and clearance of pathogens and foreign antigens entering the bloodstream through a highly specialized network of liver‐adapted immune cells. Mapping the immune resident compartment in the liver has been challenging because it requires multimodal single‐cell deep phenotyping approaches of often rare cell populations in difficult to access samples. Recently, emerging single‐cell technologies have been applied to the diverse array of immune cells present in murine and human livers, and here we summarize how they have advanced or redefined our understanding of the immunological barrier provided by the liver.

]]>