ResearchPad - tissue‐specific-stem-cells https://www.researchpad.co Default RSS Feed en-us © 2020 Newgen KnowledgeWorks <![CDATA[MiRNA‐137‐mediated modulation of mitochondrial dynamics regulates human neural stem cell fate]]> https://www.researchpad.co/article/elastic_article_8253 miR‐137 facilitates neuronal differentiation of neural stem cells by enhancing mitochondrial biogenesis, fusion, fission, and OXPHOS. miR‐137 downregulates MEF2A, which may reduce the transcription of PGC1α. Increased expression of nuclear factor erythroid 2 (NFE2)‐related factor 2 (NRF2) and transcription factor A of mitochondria (TFAM) by miR‐137 elevates mitochondrial biogenesis to match the need of newly generated neurons.

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<![CDATA[Transforming Growth Factor β-Activated Kinase 1 Regulates Mesenchymal Stem Cell Proliferation Through Stabilization of Yap1/Taz Proteins]]> https://www.researchpad.co/article/Na29e822b-73e4-4e16-b59c-e039cfb32974

Abstract

Bone marrow‐derived mesenchymal stem cells (BMMSCs) are multipotent stem cells capable of differentiation into a variety of cell types, proliferation, and production of clinically useful secretory factors. These advantages make BMMSCs highly useful for cell transplantation therapy. However, the molecular network underlying BMMSC proliferation remains poorly understood. Here, we showed that TGFβ‐activated kinase 1 (Tak1) is a critical molecule that regulates the activation of cell cycling and that Tak1 inhibition leads to quiescence in BMMSCs both in vivo and in vitro. Mechanistically, Tak1 was phosphorylated by growth factor stimulations, allowing it to bind and stabilize Yap1/Taz, which could then be localized to the nucleus. We also demonstrated that the quiescence induction by inhibiting Tak1 increased oxidized stress tolerance and improved BMMSC engraftment in intramuscular and intrabone marrow cell transplantation models. This study reveals a novel pathway controlling BMMSC proliferation and suggests a useful method to improve the therapeutic effect of BMMSC transplantation. stem cells 2019;37:1595–1605

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