ResearchPad - total-synthesis Default RSS Feed en-us © 2020 Newgen KnowledgeWorks <![CDATA[Total Synthesis of a Mycolic Acid from <i>Mycobacterium tuberculosis</i> ]]> The total synthesis of four methoxy mycolic acid diastereomers is described. Key steps involve a Suzuki–Fu cross‐coupling, an anti‐selective Abiko–Masamune asymmetric aldol reaction, and an enantioselective Charette cyclopropanation. CD1b‐free mycolic acid tetramer staining experiments clearly favoured one diastereomer over the other three.